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Highly clinically substantial. Stay clear of mixtures; the potential risk of the interaction outweighs the advantage.If you take tadalafil for pulmonary arterial hypertension, never consider Cialis® or other PDE5 inhibitors, for instance sildenafil (Revatio® or Viagra®) or vardenafil (Levitra®). Cialis® also includes tadalafil. If you are taki